Woman getting an injection from a doctor via syringe.

SCHOTT TOPPAC® freeze Ready-to-use prefillable polymer syringes for deep-cold storage drugs

Name: SCHOTT TOPPAC® freeze
Brand: SCHOTT Pharma

Overview

Pushing boundaries in deep-cold drug storage with SCHOTT TOPPAC® freeze prefillable polymer syringes

Pharma companies are facing growing challenges in meeting deep-cold storage requirements. SCHOTT TOPPAC® freeze is the first ready-to-use prefillable polymer syringe for deep-cold drugs tested for temperatures down to -180 °C, offering reliable containment and the safe delivery of drugs that require deep cold storage conditions.

Made from high-quality Cyclic Olefin Copolymer (COC), this prefillable polymer syringe for deep-cold drugs provides excellent barrier properties, no ion or metal release, low protein adsorption, and full compliance with EP, JP, and USP Class VI standards.

With advanced quality control, automated repeatable processes and a comprehensive data package on deep cold storage performance, SCHOTT TOPPAC® freeze also comes with complete documentation for safe and effective administration.

Benefits

Protecting drug integrity in deep-cold drug storage

SCHOTT TOPPAC® freeze polymer syringes are accompanied by an extensive data package that covers complete performance characteristics for its intended use at low temperatures. Enhanced quality control and specifications also ensure optimal drug containment for filling, transport, and storage, even after thawing.

As a trusted partner in mRNA therapeutics, we leverage our extensive experience to address the challenges of deep-cold drug storage and deliver effective solutions for cryogenic storage.

Container closure integrity to rely on

Proven container closure integrity (CCI) at -180 °C

Validated for deep-cold performance

Complete data package on syringe functionality for its intended use

Low extractables, high performance

Cross-linked silicone for lower extractable silicone quantities and lower sub-visible particles

Enhanced quality standards

Improved quality control and specifications for critical quality attributes

Applications

Optimized cold storage for deep-frozen medications

An increasing number of modern therapies require cryogenic storage to maintain stability throughout the supply chain. This includes mRNA-based treatments, cell and gene therapies, certain chemotherapy drugs, and viral vectors such as the adeno-associated virus (AAV).

SCHOTT TOPPAC® freeze syringes offer a reliable containment solution for biopharmaceutical cold storage, with proven performance at temperatures down to -180 °C. Manufactured in a cleanroom using a fully automated process, the prefillable polymer syringes for deep-cold drugs are supplied in a ready-to-use nest-and-tub configuration. Their suitability for frozen drug delivery is backed by application-specific stability studies, including LNP and protein formulations.

Specifications


Product Name	Product Name SCHOTT TOPPAC® freeze	Product Name SCHOTT TOPPAC® cosmetic	Product Name SCHOTT TOPPAC® infuse	Product Name SCHOTT TOPPAC® cartridge	Product Name SCHOTT TOPPAC® unique	Product Name SCHOTT TOPPAC®
Applications	Applications Deep-frozen medications	Applications Aesthetic treatments	Applications Large-volume applications and infusion therapy	Applications Biologics	Applications Unique formulations that require tailored primary packaging solutions	Applications Biologics, aesthetic treatments, long-acting release formulations, and large-volume applications
Tubing Container Material	Tubing Container Material Advanced Cyclic Olefin Copolymer (COC)	Tubing Container Material Advanced Cyclic Olefin Copolymer (COC)	Tubing Container Material Advanced Cyclic Olefin Copolymer (COC)	Tubing Container Material Advanced Cyclic Olefin Copolymer (COC)	Tubing Container Material Advanced Cyclic Olefin Copolymer (COC)	Tubing Container Material Advanced Cyclic Olefin Copolymer (COC)
Format	Format 1 - 3 ml	Format 1 - 3 ml	Format 5 - 50 ml	Format 1.5 ml, 3 ml, 5 ml, and 10 ml (in development)	Format Customizable	Format 1 - 50 ml
Closure Systems	Closure Systems Rigid Tip Cap	Closure Systems Rigid Tip Cap	Closure Systems Tip Cap, Rigid Tip Cap and Tamper-Evident Closure System	Closure Systems Seal	Closure Systems Customizable	Closure Systems Tip Cap, Rigid Tip Cap and Tamper-Evident Closure System
Pre-washed, Pre-sterilized	Pre-washed, Pre-sterilized RTU	Pre-washed, Pre-sterilized RTU	Pre-washed, Pre-sterilized RTU	Pre-washed, Pre-sterilized RTU	Pre-washed, Pre-sterilized RTU	Pre-washed, Pre-sterilized RTU
Packaging	Packaging Pre-sterilized syringes in tub- and nest-configuration	Packaging Pre-sterilized syringes in tub- and nest-configuration	Packaging Pre-sterilized syringes in tub- and nest-configuration	Packaging Pre-sterilized cartridges in tub- and nest configuration	Packaging Customizable	Packaging Pre-sterilized syringes in tub- and nest-configuration

		Read More	Read More	Read More	Read More	Read More

Key insights about low-temperature mRNA vaccine packaging

What you need to know about selecting polymer syringes for low-temperature mRNA vaccines.

Whitepaper preview about packaging low-temperature mRNA vaccines

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